Name: Paul Matthews, MD, DPhil

Title: Professor and Head

Centre: Department of Brain Sciences, Imperial College, London

Clinical Interests:

  • Multiple Sclerosis
  • Alzheimer’s Disease
  • Advanced Imaging Techniques
  • Early Phase Pharmaceutical Development
  • Mechanisms of neuroinflammation and neurodegeneration


Paul Matthews, OBE, MD, DPhil, FRCP, FMedSci is the Edmond and Lily Safra Professor of Translational Neuroscience and Therapeutics, Head of the Department of Brain Sciences, a Director of the UK Dementia Research Institute, an Associate Director of the Data Science Institute at Imperial College London and Chair of the UKRI Medical Research Council Neurosciences and Mental Health Board. Since 2009, he has been on the Steering Committee of UK Biobank and chairs the Imaging Enhancement Working Group, which is supporting UK Biobank for creating the world’s largest imaging epidemiological dataset. He recently has led the development of the OPTIMISE Pharmacovigilance Study, an academic initiated academic-industry partnership to prospectively acquire real world date concerning the safety of disease modifying therapies for multiple sclerosis. His laboratory-based research addresses neuroinflammatory mechanisms of neurodegeneration in Alzheimer’s disease and progressive multiple sclerosis.

Previously, Matthews spent almost 9 years as a Vice President in GlaxoSmithKline, holding a variety of senior portfolios, including those for the GSK Clinical Imaging Centre and the later Global Imaging Group. He founded the Oxford FMRIB Centre, which he directed from 1995-2005. He is a Fellow of the Academy of Medical Sciences, a Fellow by Special Election of St Edmund Hall, Oxford and a Fellow of the Academea Europea. He was awarded an OBE in 2008 for services to Neuroscience.